2026
2025
Inhibition of Hippo Signaling Through Ablation of Lats1 and Lats2 Protects Against Cognitive Decline in 5xFAD Mice via Increasing Neuronal Resilience Against Ferroptosis
Ligand-receptor interactions induce and mediate regulatory functions of BATF3(+) B cells
Selective inhibition of BRAF and CRAF sensitizes NF1-deficient malignant peripheral nerve sheath tumors to MEK inhibitors
Dual inhibition of MAPK and TORC1 signaling retards development of radiation resistance in pediatric BRAFV600E glioma models
Epigenetic silencing of DNA sensing pathway by FOXM1 blocks stress ligand-dependent antitumor immunity and immune memory
Benchmarking mouse contamination removing protocols in patient-derived xenografts genomic profiling
2024
2023
Genomic profiling of subcutaneous patient-derived xenografts reveals immune constraints on tumor evolution in childhood solid cancer
Comprehensive characterization of patient-derived xenograft models of pediatric leukemia
Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibition attenuates DNA double-strand break repair and augments the efficacy of temozolomide in glioblastoma
DepLink: an R Shiny app to systematically link genetic and pharmacologic dependencies of cancer
OpenPBTA: The Open Pediatric Brain Tumor Atlas
Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow-Derived Macrophages
2022
Protocol to benchmark gene expression signature scoring techniques for single-cell RNA sequencing data in cancer
Natural Coevolution of Tumor and Immunoenvironment in Glioblastoma
Genomic disparities between cancers in adolescent and young adults and in older adults
Inhibition of LIFR Blocks Adiposity-Driven Endometrioid Endometrial Cancer Growth
M6A RNA Methylation Regulates Histone Ubiquitination to Support Cancer Growth and Progression
Signature-scoring methods developed for bulk samples are not adequate for cancer single-cell RNA sequencing data
Approaches to identifying drug resistance mechanisms to clinically relevant treatments in childhood rhabdomyosarcoma
2021
SNAI2-Mediated Repression of BIM Protects Rhabdomyosarcoma from Ionizing Radiation
Predicting and characterizing a cancer dependency map of tumors with deep learning
Regulation of telomere homeostasis and genomic stability in cancer by N (6)-adenosine methylation (m(6)A)
A modular master regulator landscape controls cancer transcriptional identity
PCAT: an integrated portal for genomic and preclinical testing data of pediatric cancer patient-derived xenograft models
Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation
2020
Deep learning of pharmacogenomics resources: moving towards precision oncology
Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution
Development and characterization of the novel human osteosarcoma cell line COS-33 with sustained activation of the mTOR pathway
MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome
EGFR Amplification Induces Increased DNA Damage Response and Renders Selective Sensitivity to Talazoparib (PARP Inhibitor) in Glioblastoma
Prospective use of the single-mouse experimental design for the evaluation of PLX038A
2019
Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design
Tie2-FGFR1 Interaction Induces Adaptive PI3K Inhibitor Resistance by Upregulating Aurora A/PLK1/CDK1 Signaling in Glioblastoma
Synonymous but Not Silent: A Synonymous VHL Variant in Exon 2 Confers Susceptibility to Familial Pheochromocytoma and von Hippel-Lindau Disease
PELP1 promotes glioblastoma progression by enhancing Wnt/β-catenin signaling
Prospective Clinical Sequencing of Adult Glioma
2018
Profiles of brain metastases: Prioritization of therapeutic targets
Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma
Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma
Activation of WEE1 confers resistance to PI3K inhibition in glioblastoma
TumorFusions: an integrative resource for cancer-associated transcript fusions
2017
ARID1B alterations identify aggressive tumors in neuroblastoma
Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment
Benchmarking: contexts and details matter
Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma
Multigene signature for predicting prognosis of patients with 1p19q co-deletion diffuse glioma
APOBEC3G acts as a therapeutic target in mesenchymal gliomas by sensitizing cells to radiation-induced cell death
Preclinical therapeutic efficacy of a novel blood-brain barrier-penetrant dual PI3K/mTOR inhibitor with preferential response in PI3K/PTEN mutant glioma
Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles
Systematic analysis of telomere length and somatic alterations in 31 cancer types
Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation
2016
MSK1-Mediated β-Catenin Phosphorylation Confers Resistance to PI3K/mTOR Inhibitors in Glioblastoma
Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma
Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma
2015
Hepatocyte Growth Factor/cMET Pathway Activation Enhances Cancer Hallmarks in Adrenocortical Carcinoma
The landscape and therapeutic relevance of cancer-associated transcript fusions
Molecular profiling of long-term survivors identifies a subgroup of glioblastoma characterized by chromosome 19/20 co-gain
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas
Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution
Advances in computational genomics
2014
Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin
PRADA: pipeline for RNA sequencing data analysis
The Pan-Cancer analysis of pseudogene expression reveals biologically and clinically relevant tumour subtypes
Silent mutations make some noise
Molecular subtypes of glioblastoma are relevant to lower grade glioma
ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state
A high Notch pathway activation predicts response to γ secretase inhibitors in proneural subtype of glioma tumor-initiating cells
2013
Intragenic breakpoint: a marker of genome instability in glioblastoma
The somatic genomic landscape of glioblastoma
The Cancer Genome Atlas Pan-Cancer analysis project
A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival
Intravenous glial growth factor 2 (GGF2) isoform of neuregulin-1β improves left ventricular function, gene and protein expression in rats after myocardial infarction
2012
Connectivity map analysis of nonsense-mediated decay-positive BMPR2-related hereditary pulmonary arterial hypertension provides insights into disease penetrance
DNA methylation profiling distinguishes three clusters of breast cancer cell lines
GenRev: exploring functional relevance of genes in molecular networks
Role of insulin-like growth factor-1 signaling pathway in cisplatin-resistant lung cancer cells
Studying a complex tumor: potential and pitfalls
2011
Integrative network analysis identifies key genes and pathways in the progression of hepatitis C virus induced hepatocellular carcinoma
Association of feature gene expression with structural fingerprints of chemical compounds
Epithelial cell organization suppresses Myc function by attenuating Myc expression
dmGWAS: dense module searching for genome-wide association studies in protein-protein interaction networks
2010
Hdac3 is essential for the maintenance of chromatin structure and genome stability
A comparative analysis of liver transcriptome suggests divergent liver function among human, mouse and rat
Identification of p27/KIP1 expression level as a candidate biomarker of response to rapalogs therapy in human cancer
PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach
Discovering disease-specific biomarker genes for cancer diagnosis and prognosis
2009
2008
2006
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